In: 2021 IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB), pp. 1–7. Mayya, V., Kamath, S.S., Sugumaran, V.: Label attention transformer architectures for ICD-10 coding of unstructured clinical notes. Insights on open challenges and directions for future research are also discussed. We detail the various tools and methods that have been developed for variant annotation along with datasets that have been used by these methods. In this paper, a comprehensive review of current work addressing the problem of variant annotation is presented. This is an interesting problem in the computational biology field and presents many open challenges that are yet to be addressed. Once genomic sequencing data is processed, and variants are called, it is vital to recognise the functional content of this data and then analyse the data to prioritise these variants. The outcomes of such annotation are beneficial because they can directly influence the conclusions arrived at in disease studies. Words of Wisdom by AnneCN is licensed under a CC BY 2.0 Licence.Variant annotation is the process by which variants and mutations in the DNA are assigned functional information and is a crucial process in genomic sequence analysis.This chapter was adapted from “ Annotate and Take Notes” in The Word on College Reading and Writing by Carol Burnell, Jaime Wood, Monique Babin, Susan Pesznecker, and Nicole Rosevear, which is licensed under a CC BY-NC 4.0 Licence.When you’re finished, write a quick summary-several sentences or a short paragraph-that captures the article’s main points.Then look them up! ( is a good online dictionary and even pronounces words so you’ll know how they sound.) Circle all words you don’t understand.Write question marks in the margin where questions occur to you, and make written margin notes about them, too.Make notes in the margins as ideas occur to you. As you read, underline points that you find especially interesting.The thesis statement can occur anywhere in the article-even near the end.) ![]() (The thesis statement is one or two sentences that summarizes the article’s main point and tells what it’s about. Underline what you believe to be the topic or thesis statement in the article.Then read the article completely, annotating as you go. Pre-read the article to gather some first impression ideas.Print a hard copy of the CBC News article, “ New Westminster offers $4M worth of free land for affordable housing.” If you aren’t able to print a hard copy, carry out the following instructions using a piece of paper and a pen or pencil. Writing in the text with a simple pen or pencil is always preferable. Using them creates big swaths of eye-popping colour in your text, but when you later go back to them, you may not remember why they were highlighted. ![]() These are better than nothing, but in truth, they’re not much help. Many students use brightly-coloured highlighting pens to mark up texts. For a strategy that helps you take note of what you see as interesting or important points of a text while also responding to those points with your own ideas, see “ Dialectic Note-taking” in this text. You might also choose to use sticky notes to capture your ideas-these can be stuck to specific pages for later recall. ![]() ![]() If you can’t write on the text itself, you can accomplish almost the same thing by taking notes-either by hand (on paper) or e-notes. Note that I say most-if you have questions about your own institution and plan to sell back any textbooks, be sure to ask at the bookstore before you annotate. In other words, you can annotate a textbook and still sell it back to the bookstore later on if you choose to. Important note: most academic institution bookstores approve of textual annotation and don’t think it decreases a textbook’s value. If you don’t make notes as you go, today’s great observation will likely become tomorrow’s forgotten detail. You might underline important sections, circle words you don’t understand, and use your own set of symbols to highlight portions that you feel are important.Ĭapturing these ideas as they occur to you is important, for they may play a role in not just understanding the text better but also in your college assignments. You can jot down questions and ideas as they come to you. Writing in your texts as you read-annotating them-is a powerful strategy for engaging with a text and entering a discussion with it. As children, most of us were told never to write in books, but now that you’re an adult student, your instructor will tell you just the opposite.
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